This groundbreaking research reveals the physical architecture of memory engrams in the mouse hippocampus, pushing the boundaries of neuroscience through the integration of artificial intelligence with advanced 3D electron microscopy. By combining chemogenetic tagging of neurons with AI-driven image segmentation, the researchers achieved an unprecedented nanoscale reconstruction of hippocampal circuits involved in memory. Contrary to classical Hebbian theory, they found that neurons active during memory formation do not preferentially wire with each other; instead, they expand their connectivity via complex multisynaptic boutons (MSBs), enabling broader and more flexible information encoding. These structural changes were accompanied by synapse-specific enlargement, mitochondrial remodeling, and altered interactions with astrocytes—signatures linked specifically to negative-valence associative learning. The findings challenge traditional models of memory storage and suggest a novel mechanism where synaptic complexity, not just strength or density, enhances memory capacity. Overall, this study provides a structural foundation for understanding how the brain encodes, generalizes, and maintains long-term memories.

This discussion between OpenAI's Chief Economist Ronnie Chatterji and LinkedIn’s Chief Economist Karin Kimbrough explores the current and future impact of generative AI on the labor market, highlighting macroeconomic dynamics, evolving skill demands, and global disparities in AI adoption. Kimbrough offers labor market insights based on LinkedIn data, while Chatterji connects these to policy, infrastructure, and human-centered innovation themes promoted by OpenAI.

At the OpenAI Forum’s debut event in Asia, a groundbreaking collaboration with the Peranakan Museum, Singapore’s National Heritage Board, and Ask Mona demonstrated how AI can transform cultural engagement. Visitors now interact directly with artifacts through personalized, multilingual dialogues, highlighting AI’s potential to democratize access to heritage, deepen curiosity, and spark civic belonging.